Table 1 Significantly-regulated proteins that are known to associated with chemoresistance in NB cell line SK-N-BE (2) compared with SK-N-BE (1)
Protein ID | Protein name | Gene name | Folds ratioa | Related cancer/Tumor |
|---|---|---|---|---|
Up-regulated proteins | ||||
Galectin-1 | LGALS1 | 12.91 | chronic myeloid leukemia, hepatocellular carcinoma, Neuroblastoma | |
Q9Y244 [42] | Proteasome maturation protein | POMP | 6.61 | multiple myeloma |
P08183 [43] | Multidrug resistance protein 1 | ABCB1 | 4.99 | bladder cancer, osteosarcoma, colorectal cancer, breast cancer, neuroblastoma, chronic myeloid leukemia, ovarian cancer, lung cancer, etc. |
Q96D09 [44] | G-protein coupled receptor-associated sorting protein 2 | GPRASP2 | 4.68 | basal cell carcinoma, medulloblastoma |
Q06830 [45] | Peroxiredoxin-1 | PRDX1 | 2.81 | pancreatic cancer, cervical cancer |
P04049 [46] | RAF proto-oncogene serine/threonine-protein kinase | BRAF | 2.72 | melanoma, colorectal cancer, gliomas |
P49407 [47] | Beta-arrestin-1 | ARRB1 | 2.59 | ovarian cancer |
Alpha-enolase | ENO1 | 2.40 | nasopharyngeal carcinoma, ovarian cancer | |
P50570 [49] | Dynamin-2 | DNM2 | 2.19 | chronic myeloid leukemia |
P35080 [50] | Profilin-2 | PFN2 | 2.05 | colon cancer |
Down-regulated proteins | ||||
Q02880 [51] | DNA topoisomerase 2-beta | TOP2B | 0.49 | breast cancer, colorectal carcinoma |
DNA repair protein complementing XP-G cells | ERCC5 | 0.38 | Neuroblastoma, lung cancer, colon cancer, renal cancer, ovarian cancer, etc. | |
Mothers against decapentaplegic homolog 4 | SMAD4 | 0.33 | pancreatic carcinoma, hepatocellular carcinoma, colon cancer, lung cancer | |
Q92466 [56] | DNA damage-binding protein 2 | DDB2 | 0.21 | colon cancer, ovarian cancer |
Q13472 [57] | DNA topoisomerase 3-alpha | TOP3A | 0.18 | ovarian cancer, breast cancer, lung cancer |
P34931 [58] | Heat shock 70 kDa protein 1-like | HSPA1L | 0.05 | osteosarcoma, breast cancer, colorectal adenocarcinoma |