Fig. 2
From: Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasis
Combined treatment of J-4 and Celecoxib synergistically inhibited the invasion of melanoma cells. (a and b) The invasion of B16-F10 (a) and A375 (b) cells was significantly inhibited by a 24-h treatment of the combination of J-4 (25 μM) and Celecoxib (25 μM) assessed via Transwell assay. (c and d) The dose-effect curve and CI of the synergistic effect of J-4 with Celecoxib in A375 (c) and B16-F10 (d) cells calculated by the CalcuSyn software 2.1. * P < 0.05; ** P < 0.01