Fig. 3From: Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasisThe combination of J-4 and Celecoxib significantly inhibited the migration of melanoma cells. (a and b) Wound healing assay results in B16-F10 cells with various treatments for 3, 6, 9, 12, and 24 h. (c and d) Wound healing assay results in A375 cells with various treatments for 3, 6, 9, 12, and 24 h. The migration distance was measured by a software-based method. J-4: 25 μM; Celecoxib: 25 μM. * P < 0.05; ** P < 0.01Back to article page