Fig. 6

Cathepsin L links autophagy and DNA damage repair to the radiosensitivity effect of TFP. a Activity of cathepsin B and L after treatment with PBS (control) and 5 μM TFP. b Western blot analysis of cathepsin B heavy chain, procathepsin B and cathepsin L after different TFP treatment doses (0-10 μM). c Western blots for cathepsin L, P62, Rad51 and γ-H2AX in U251 and U87 cells before and after cathepsin L knock-down. d HR activity of U251 and U87 before and after cathepsin L knock down. **P < 0.01; ***P < 0.001