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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma

Fig. 1

Increased NLRP3 inflammasome is correlated with CSCs markers BMI1, ALDH1 and CD44 in human SCCHN. a Representative Immunohistochemistry staining of NLRP3 inflammasome components (NLRP3, Caspase-1, ASC, and IL-18) and cancer stem cell markers BMI1, ALDH1 and CD44 in oral mucosa (left) and in human SCCHN tissue (right). Scale bar = 50 μm. b BMI1 expression was statistically associated with NLRP3 (P < 0.001, r = 0.3169), Caspase-1(P < 0.001, r = 0.3365), and IL-18 (P < 0.001, r = 0.3447) but not with ASC (P > 0.05, r = 0.1705), c ALDH1 expression was statistically associated with NLRP3 (P < 0.001, r = 0.6613), Caspase-1 (P < 0.001, r = 0.6934), ASC (P < 0.001, r = 0.4821) and IL-18 (P < 0.001, r = 0.6632), and d CD44 was statistically associated with NLRP3 (P < 0.001, r = 0.4206), Caspase-1 (P < 0.001, r = 0.5161), ASC (P < 0.001, r = 0.4615) and IL-18 (P < 0.001, r = 0.6014) by Pearson’s correlation coefficient test. e Hierarchical clustering of NLRP3, Caspase-1, ASC, IL-18, BMI1, ALDH1, and CD44. Immunohistochemical staining was clustered with cluster and visualized with Java Treeview

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