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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

Fig. 1

Selective killing effects of Sophoridine on cancer cells. a chemical structure of Sophoridine. b IC50 of Sophoridine for various cancer cells and normal cells. Normal cells, including human ovarian epithelial cells (IOSE144), human hepatic immortal cells (HL-7702 and LO2), immortalized human bronchial epithelial cells (BEAS-2B), human gastric epithelial cells (GES-1), human embryonic kidney (HEK) 293 T, human pancreatic ductal epithelial cell (HPDE), human colon epithelial cell (FHC), and a variety of human cancer cell lines, were treated with Sophoridine (0, 3.9, 7.8, 15.5, 31, 62.5, 125, 250, 500 μmol/L) for 48 h. Cytotoxicity was assessed with a CCK-8 assay, and IC50 values for Sophoridine on multiple cell lines were calculated by SPSS statistical software (SPSS Inc., Chicago, IL, USA). The results are representatives of at least 3 independent experiments

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