Skip to main content
Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells

Fig. 7

Annexin A2 is overexpressed and associated with poor prognosis in human lung cancer. a-b Immunohistochemistry analysis of Annexin A2 protein levels in lung cancer specimens and adjacent normal tissues. a Representative immunohistochemical staining examples of Annexin A2 protein expression in adjacent normal tissues and four different lung cancer tissues (Scale bar, 50 μm). The lung cancer tissue sections were quantitatively scored according to the percentage of positive cells and staining intensity as described in Materials and Methods. The percentage and intensity scores were multiplied to obtain a total score (range, 0–12), and the tumors were finally determined as negative (−), score 0; lower expression (+), score ≤ 4; moderate expression (++), score 5–8; and high expression (+++), score ≥ 9; b Annexin A2 expression scores in lung cancer specimens and adjacent normal tissues. *P < 0.05. c Kaplan–Meier OS curves (http://www.kmplot.com/lung) of 1926 lung cancer patients relative to different expression levels of Annexin A2 (probe 201590_x_at). d Kaplan–Meier OS curves (http://kmplot.com/analysis/) of 176 lung cancer patients administered chemotherapy relative to different expression levels of Annexin A2. e Kaplan–Meier OS curves (http://kmplot.com/analysis/) of 310 lung cancer patients without chemotherapy relative to different expression levels of Annexin A2

Back to article page