Fig. 4

ASIC2 promotes metastasis of CRC cells in vivo. a, b Cells were injected into the distal tip of the spleen and mice were euthanized after 6 weeks. Metastatic nodules in the liver were counted. ASIC2 overexpression in SW480 cells resulted in more metastatic foci in the liver. c, d ASIC2 knockdown inhibited liver metastasis of SW620 cells. *p < 0.05, **p < 0.01