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Table 1 Correlation between ASIC2 expression and clinicopathological characters in colorectal cancer tissues from 147 patients

From: The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis

Clinicopathologic features No. of patients (%) ASIC2a status P value
Low (n = 83) No. (%) High (n = 64) No. (%)
Gender Male 90 (61.2) 44 (48.9) 46 (51.1) 0.020
Female 57 (38.8) 39 (68.4) 18 (31.6)
Age ≤58 66 (44.9) 44 (66.7) 22 (33.3) 0.024
>58 81 (55.1) 39 (48.1) 42 (51.9)
Location Rectum 78 (53.0) 46 (59.0) 32 (41.0) 0.514
Colon 69 (46.9) 37 (53.6) 32 (46.4)
Histological classification Tubular 131 (89.1) 73 (55.7) 58 (44.3) 0.606
Mucinous 16 (10.9) 10 (62.5) 6 (37.5)
Tumor size (cm) ≤4 74 (50.0) 40 (54.1) 34 (45.9) 0.553
>4 73 (50.0) 43 (58.9) 30 (41.1)
Differentiation degree Well 16 (10.9) 9 (56.3) 7 (43.7) 0.940
Moderate 103 (70.1) 59 (57.3) 44 (42.7)
Poor 28 (19.0) 15 (53.6) 13 (46.4)
Recurrence status Positive 22 (15.0) 4 (18.2) 18 (81.8) 0.000
Negative 125 (85.0) 79 (63.2) 46 (36.8)
T-stage T1 4 (2.7) 1 (25.0) 3 (75.0) 0.040
T2 56 (38.1) 39 (69.6) 17 (30.4)
T3 83 (56.5) 42 (50.6) 41 (49.4)
T4 4 (2.7) 1 (25.0) 3 (75.0)
Lymph node metastasis Negative 117 (79.6) 67 (57.3) 50 (42.7) 0.698
Positive 30 (20.4) 16 (53.3) 14 (46.7)
Distant metastasis M0 111 (75.5) 68 (61.3) 43 (38.7) 0.039
M1 36 (29.4) 15 (41.7) 21 (58.3)
TNM stage I 47 (32.0) 32 (68.1) 15 (31.9) 0.084
II 49 (33.3) 26 (53.1) 23 (46.9)
III 15 (10.2) 10 (66.7) 5 (33.3)
IV 36 (24.5) 15 (41.7) 21 (58.3)
NFAT1 Negative 86 (58.5) 56 (65.1) 30 (34.9) 0.018
Positive 61 (41.5) 27 (44.3) 34 (55.7)