Table 1 Correlation between ASIC2 expression and clinicopathological characters in colorectal cancer tissues from 147 patients
Clinicopathologic features | No. of patients (%) | ASIC2a status | P value | ||
|---|---|---|---|---|---|
Low (n = 83) No. (%) | High (n = 64) No. (%) | ||||
Gender | Male | 90 (61.2) | 44 (48.9) | 46 (51.1) | 0.020 |
Female | 57 (38.8) | 39 (68.4) | 18 (31.6) | ||
Age | ≤58 | 66 (44.9) | 44 (66.7) | 22 (33.3) | 0.024 |
>58 | 81 (55.1) | 39 (48.1) | 42 (51.9) | ||
Location | Rectum | 78 (53.0) | 46 (59.0) | 32 (41.0) | 0.514 |
Colon | 69 (46.9) | 37 (53.6) | 32 (46.4) | ||
Histological classification | Tubular | 131 (89.1) | 73 (55.7) | 58 (44.3) | 0.606 |
Mucinous | 16 (10.9) | 10 (62.5) | 6 (37.5) | ||
Tumor size (cm) | ≤4 | 74 (50.0) | 40 (54.1) | 34 (45.9) | 0.553 |
>4 | 73 (50.0) | 43 (58.9) | 30 (41.1) | ||
Differentiation degree | Well | 16 (10.9) | 9 (56.3) | 7 (43.7) | 0.940 |
Moderate | 103 (70.1) | 59 (57.3) | 44 (42.7) | ||
Poor | 28 (19.0) | 15 (53.6) | 13 (46.4) | ||
Recurrence status | Positive | 22 (15.0) | 4 (18.2) | 18 (81.8) | 0.000 |
Negative | 125 (85.0) | 79 (63.2) | 46 (36.8) | ||
T-stage | T1 | 4 (2.7) | 1 (25.0) | 3 (75.0) | 0.040 |
T2 | 56 (38.1) | 39 (69.6) | 17 (30.4) | ||
T3 | 83 (56.5) | 42 (50.6) | 41 (49.4) | ||
T4 | 4 (2.7) | 1 (25.0) | 3 (75.0) | ||
Lymph node metastasis | Negative | 117 (79.6) | 67 (57.3) | 50 (42.7) | 0.698 |
Positive | 30 (20.4) | 16 (53.3) | 14 (46.7) | ||
Distant metastasis | M0 | 111 (75.5) | 68 (61.3) | 43 (38.7) | 0.039 |
M1 | 36 (29.4) | 15 (41.7) | 21 (58.3) | ||
TNM stage | I | 47 (32.0) | 32 (68.1) | 15 (31.9) | 0.084 |
II | 49 (33.3) | 26 (53.1) | 23 (46.9) | ||
III | 15 (10.2) | 10 (66.7) | 5 (33.3) | ||
IV | 36 (24.5) | 15 (41.7) | 21 (58.3) | ||
NFAT1 | Negative | 86 (58.5) | 56 (65.1) | 30 (34.9) | 0.018 |
Positive | 61 (41.5) | 27 (44.3) | 34 (55.7) | ||