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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: High expression of Bruton’s tyrosine kinase (BTK) is required for EGFR-induced NF-κB activation and predicts poor prognosis in human glioma

Fig. 1

High expression of BTK correlates with poor outcome in glioma patients. (a) Total protein extracts isolated from non-tumorous brain tissues and glioma tissues were evaluated through western blotting analysis. (b) The mRNA expression of BTK was high in glioma patients. Microarray gene expression data were obtained from GEO database (accession number GSE16011). (c) Kaplan-Meier survival analysis of glioma patients was performed using GEO dataset (accession number GSE16011). BTK was high expression in 152 out of 273 glioma cases. (d) Overall survival analysis of lower grade glioma (LGG) patients was performed using TCGA LGG dataset. (e) Overall survival analysis of GBM patients was performed using TCGA GBM dataset. (f) Event-free survival analysis of GBM patients was performed using TCGA GBM dataset

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