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Table 3 Univariate and multivariate Cox proportional hazard models for disease free survival (DFS)

From: miR-19b-3p promotes colon cancer proliferation and oxaliplatin-based chemoresistance by targeting SMAD4: validation by bioinformatics and experimental analyses

 

Disease free survival (DFS)

Univariate

Multivariate

HR (95% CI)

P

HR (95% CI)

P

Age

  < 65 y

1

  ≥ 65 y

1.76 (0.97–2.68)

0.079

Gender

 Male

1

 Female

1.53 (0.93–2.31)

0.372

Location

 Left

1

 Others

0.74 (0.52–1.39)

0.354

T stage

 T1 + T2

1

 T3 + T4

1.85 (0.56–5.37)

0.482

N stage

 N0

1

1

 N1 + N2

5.26 (2.42–10.46)

<0.001*

4.21 (2.50–7.94)

<0.001*

AJCC stage

 II

1

1

 III

6.82 (3.72–10.93)

<0.001*

2.29 (1.21–3.82)

0.381

Histologic grade

 Well Differentiated

1

1

 Poorly differentiated

2.83 (1.79–4.29)

<0.001*

2.20 (1.35–3.62)

0.282

Venous & Lymphatic invasion

 No

1

 Yes

0.72 (0.56–1.27)

0.413

Peritoneal Dissemination

 Absent

1

 Present

0.84 (0.68–1.53)

0.281

Liver Metastsis

 Negative

1

1

 Positive Multinodular

0.52 (0.29–0.83)

0.003*

0.69 (0.36–1.23)

0.032*

MiR-19b-3p

 Low

1

1

 High

3.34 (1.97–5.23)

<0.001*

2.73 (1.76–3.89)

0.016*

  1. HR: Hazard ratio; CI: Confidence interval
  2. *P < 0.05 was considered significant