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Table 3 Univariate and multivariate Cox proportional hazard models for disease free survival (DFS)

From: miR-19b-3p promotes colon cancer proliferation and oxaliplatin-based chemoresistance by targeting SMAD4: validation by bioinformatics and experimental analyses

  Disease free survival (DFS)
Univariate Multivariate
HR (95% CI) P HR (95% CI) P
Age
  < 65 y 1
  ≥ 65 y 1.76 (0.97–2.68) 0.079
Gender
 Male 1
 Female 1.53 (0.93–2.31) 0.372
Location
 Left 1
 Others 0.74 (0.52–1.39) 0.354
T stage
 T1 + T2 1
 T3 + T4 1.85 (0.56–5.37) 0.482
N stage
 N0 1 1
 N1 + N2 5.26 (2.42–10.46) <0.001* 4.21 (2.50–7.94) <0.001*
AJCC stage
 II 1 1
 III 6.82 (3.72–10.93) <0.001* 2.29 (1.21–3.82) 0.381
Histologic grade
 Well Differentiated 1 1
 Poorly differentiated 2.83 (1.79–4.29) <0.001* 2.20 (1.35–3.62) 0.282
Venous & Lymphatic invasion
 No 1
 Yes 0.72 (0.56–1.27) 0.413
Peritoneal Dissemination
 Absent 1
 Present 0.84 (0.68–1.53) 0.281
Liver Metastsis
 Negative 1 1
 Positive Multinodular 0.52 (0.29–0.83) 0.003* 0.69 (0.36–1.23) 0.032*
MiR-19b-3p
 Low 1 1
 High 3.34 (1.97–5.23) <0.001* 2.73 (1.76–3.89) 0.016*
  1. HR: Hazard ratio; CI: Confidence interval
  2. *P < 0.05 was considered significant