Fig. 7

Activation of Wnt/β-catenin signaling is required for kindlin-2-induced HCC cell migration and invasion. a Either knockdown of β-catenin or ICG-001 treatment is able to downregulate the expression of Axin2 but not the expression of Kindlin-2. Meanwhile, ICG-001 treatment does not change β-catenin expression. Knockdown of β-catenin or ICG-001 treatment significantly abrogates Kindlin-2-induced SMMC7721 cells migration and invasion as revealed by the wound-healing assay (b) or the transwell assay (c). ICG-001 is an antagonist of Wnt/β-catenin/TCF-mediated transcription. ** represents P < 0.01