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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway

Fig. 5

Elevated expression of Par3 dissociates KIBRA/Merlin/FRMD6 complex by increasing its interaction with KIBRA. a Endogenous interaction of Par3 with KIBRA is increased in both PC3 and DU145 cells compared to PNT1B cells. b Endogenous interaction of KIBRA with Merlin and FRMD6 is attenuated in both PC3 and DU145 cells compared to PNT1B cells. c Endogenous interaction of KIBRA with LATS1 and LATS2 is attenuated in both PC3 and DU145 cells compared to PNT1B cells. d Phosphorylation of LATS and YAP is decreased and the nuclear translocation of YAP is increased in both PC3 and DU145 cells compared to that in PNT1B cells. e Knockdown of Par3 decreases the interaction of both membranous and cytoplasmic Par3 with KIBRA and restores the interaction of KIBRA with Merlin and FRMD6. f Overexpression of Par3 further enhances the interaction of Par3 with KIBRA especially in cytoplasm and attenuates the interaction of KIBRA with Merlin and FRMD6

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