Fig. 12
G-4 inhibited in vivo tumor growth. Mice were randomly divided into five groups: control, Taxol, G-4/Tax, verteporfin/Tax and celecoxib/Tax. HCT15/Tax cells (5 × 106) were subcutaneously (SC) injected into nude mice. Mice were intraperitoneally administered with Taxol, G-4, VP, celecoxib at a dose of 10, 20, 30, 20 mg/kg alone or their combination. Tumor size was measured every 7 days using a caliper, and tumor volume was calculated as 0.5 × L × W2, with L indicating length and W indicating width. G-4 significantly decreased in vivo tumor growth according to the results of calculated tumor volume a and tumor weight b. c YAP and COX-2 expression in G-4-treated nude mice samples. (n = 5 each group) **p < 0.01 compared with Taxol group, ## p < 0.01, && p < 0.01 compared with VP/Tax and Cel/Tax group respectively. Tax: Taxol, VP: verteporfin, Cel: celecoxib, G-4: GCCSysm-4