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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer

Fig. 5

YAP mediates chemoresistance in CRC cells. a Cell viability of HCT15 cells treated with indicated concentrations of Taxol for 24, 48, 72 h. b Cell viability of IMCE cells treated with indicated concentrations of Taxol for 24, 48, 72 h. c Cell viability of IMCE cells and IMCE cells with YAP transfection and treated with indicated concentrations of Taxol for 72 h. d Cell viability of HCT15 cells, HCT15 cells with YAP shRNA or COX-2 shRNA transfection and treated with indicated concentrations of Taxol for 72 h. e Cell viability in HCT8 and Taxol-resistant HCT8 (HCT8 TR) cells under the treatment of Taxol at different concentrations. **p < 0.01 compared with HCT8 cells. f Immunoblotting for YAP and COX-2 was performed in HCT8 and Taxol-resistant HCT8 (HCT8 TR) cells. Data are representative of at least three independent experiments. Error bars represent SD

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