Fig. 8

G-4 inhibited COX-2 expression and enzyme activity. a COX-2 expression in HCT8 and 15/Tax cells treated with different concentrations of G-4 (5–20 μM) for 24 h. **P < 0.01 compared with control cells. b YAP and COX-2 expression in HCT8 and 15/Tax cells transfected with YAP expressing plasmids following G-4 treatment (10 μM). **P < 0.01 compared with vehicle group. ^# P < 0.05, ^## P < 0.01 compared with G-4 0 μM group. c COX-2 enzyme activity inhibition by different concentrations of G-4 at 1, 3, 10, 30, and 100 μM. Data are representative of at least three independent experiments. Error bars represent SD