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Table 1 Biopathological characteristics of the two breast cancer sets

From: Breast carcinomas with low amplified/equivocal HER2 by Ish: potential supporting role of multiplex ligation-dependent probe amplification

Ā 

Internal set

External set

Total number of patients

170

108

Grading

ā€ƒ1

12 (7%)

17 (16%)

ā€ƒ2

76 (45%)

55 (51%)

ā€ƒ3

82 (48%)

26 (24%)

ā€ƒunknown

0 (0%)

10 (9%)

Node

ā€ƒNegative

67 (39%)

55 (51%)

ā€ƒPositive

77 (46%)

38 (35%)

ā€ƒunknown

26 (15%)

15 (14%)

HR Status

ā€ƒER and/or PgR positive

132 (78%)

99 (92%)

ā€ƒER /PgR negative

38 (22%)

9 (8%)

Ki67

ā€ƒHigh ā‰„20%

97 (57%)

52 (48%)

ā€ƒLowĀ <Ā 20%

73 (43%)

56 (52%)

HER2 gene s/n

ā€ƒ<4.0

61a (36%)

80b(74%)

ā€ƒ4.0ā€“5.9

54a(32%)

10b (9%)

ā€ƒā‰„6.0

55a (32%)

18b(17%)

  1. HR Hormonal Receptor, ER Estrogen Receptor,PgR Progesterone Receptor, s/n signals/nucleus
  2. aSilver In Situ Hybridization; bFluorescence In Situ Hybridization