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Table 1 Biopathological characteristics of the two breast cancer sets

From: Breast carcinomas with low amplified/equivocal HER2 by Ish: potential supporting role of multiplex ligation-dependent probe amplification

  Internal set External set
Total number of patients 170 108
Grading
 1 12 (7%) 17 (16%)
 2 76 (45%) 55 (51%)
 3 82 (48%) 26 (24%)
 unknown 0 (0%) 10 (9%)
Node
 Negative 67 (39%) 55 (51%)
 Positive 77 (46%) 38 (35%)
 unknown 26 (15%) 15 (14%)
HR Status
 ER and/or PgR positive 132 (78%) 99 (92%)
 ER /PgR negative 38 (22%) 9 (8%)
Ki67
 High ≥20% 97 (57%) 52 (48%)
 Low < 20% 73 (43%) 56 (52%)
HER2 gene s/n
 <4.0 61a (36%) 80b(74%)
 4.0–5.9 54a(32%) 10b (9%)
 ≥6.0 55a (32%) 18b(17%)
  1. HR Hormonal Receptor, ER Estrogen Receptor,PgR Progesterone Receptor, s/n signals/nucleus
  2. aSilver In Situ Hybridization; bFluorescence In Situ Hybridization