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Table 3 ISH and MLPA results in High Amplified/Non Amplified breast cancers in the internal and external validation set

From: Breast carcinomas with low amplified/equivocal HER2 by Ish: potential supporting role of multiplex ligation-dependent probe amplification

  DDISH (N = 116)a   FISH (N = 98)b  
  gene s/n gene s/n
  <4.0 ≥6.0 <4.0 ≥6.0
  61 55 79 19
MLPA
 NA 59 (97%) 11 (20%) 62 (79%) 2 (10.5%)
 GAIN 0 (0%) 3 (5%) 7 (9%) 2 (10.5%)
 A 2 (3%) 41 (75%) 10 (12%) 15 (79%)
  1. NA Non Amplified, A Amplified, NA < 1.3 mean value, GAIN ≥ 1.3 < 1.5 mean value, A ≥ 1.5 mean value
  2. aInternal set bExternal set