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Table 4 ISH and MLPA results in low amplified and equivocal breast cancers in the internal and external set

From: Breast carcinomas with low amplified/equivocal HER2 by Ish: potential supporting role of multiplex ligation-dependent probe amplification

  DDISH (N = 54)a FISH (N = 10)b
  4.0–5.9/=2 4.0–5.9/>2 4.0–5.9/=2 4.0–5.9/>2
  21 33 2 8
MLPA
 NA 18 (86%) 27 (82%) 0 (0%) 2 (25%)
 GAIN 2 (9%) 2 (6%) 1 (50%) 2 (25%)
 A 1 (5%) 4 (12%) 1 (50%) 4 (50%)
  1. NA Non Amplified, A Amplified, NA < 1.3 mean value, GAIN ≥1.3 < 1.5 mean value, A ≥ 1.5 mean value
  2. aInternal set: gene /CEP17 s/n bExternal set: gene /CEP17 s/n