SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis

Table 1 Association of SHCBP1 expression with the clinicopathological characteristics of SS

Variables	All patients diagnosed (n = 76)	Expression of SHCBP1		P values
Variables	All patients diagnosed (n = 76)	Low expression	High expression	P values
Gender				0.655
Male	45	11	34
Female	31	9	22
Age				0.453
≤ 35	44	13	31
> 35	32	7	25
Tumor size(cm)				0.003
≤ 5	35	15	20
> 5	41	5	36
Pathologic type				0.246
MSS	36	15	21
BSS	40	22	18
Expression of p-smad2				0.017
0–1	46	25	21
2–3	30	8	22
Expression of p-smad3				0.022
0–1	37	20	17
2–3	39	11	28
FNCLCC grade				0.003
2	32	14	18
3	44	6	38
UICC stage				0.000
1 or 2	32	16	16
3 or 4	44	4	40
Recurrence				0.024
No	50	27	23
Yes	26	7	19
Distant metastasis				0.000
M0	52	28	24
M1	24	2	22

Abbreviations: MSS monophasic synovial sarcoma, BSS biphasic synovial sarcoma, FNCLCC Federation Natinale des centres de Lutte Cotre le Cancer, UICC International Union Against Cancer

ISSN: 1756-9966