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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation

Fig. 1

Musashi-2 (MSI-2) is overexpressed in cervical cancer tissues and correlates with poor patient survival. a, Relative mRNA expression of MSI-2, EZH2 and iASPP in 58 matched human normal cervix tissues and cervical cancer (CC) tissues. b, Western blotting analysis of MSI-2 protein expression in CC cell lines and normal cervical cell line H8. c, Pan-cancer analysis of MSI-2 mRNA expression in a variety of human cancerous tissues including cervical (CESC), prostate (PRAD), bladder (BLCA), rectum (READ), endometrial (UCEC), liver (LIHC), pancreatic (PAAD), lung squamous (LUSC), esophageal (ESCA), stomach (STAD), and colon (COAD) cancer relative to their paired normal tissues using the BioExpress database. d, Analysis of MSI-2 mRNA expression in diverse cancer types including cervical, breast (BRCA), head and neck (HNSC), kidney papillary (KIRP), lung adenocarcinoma (LUAD), sarcoma (SARC), skin melanoma (SKCM), and thyroid (THCA) cancer relative to the corresponding normal tissues (MethHC database). e, Kaplan–Meier overall survival curves for 264 CC patients stratified by median MSI-2 mRNA expression (OncoLnc database). f, Kaplan-Meier plots overall survival curves for lung, pancreatic, adrenal and glioblastoma patients stratified by median MSI-2 mRNA expression (PROGgene database). * P < 0.05

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