Fig. 7

Schematic model depicting the role of the p53-miR-143/miR-107-MSI-2 axis in cervical cancer progression. Overexpression of MSI-2 upregulates the expression of c-FOS, which in turn promotes CC cell invasion, proliferation and sphere formation. Treatment with Mithramycin A restored the expression of miR-143 and miR-107 (two direct suppressors of MSI-2) via activation of p53, leading to inhibition of MSI-2 expression and reduced proliferation, invasion and sphere formation of CC cells