Fig. 2

The regulation of circRNA biogenesis. a Competitive base-pairing. Inter-intronic base-pairing promotes the biogenesis of circRNAs, while intra-intronic base-pairing inhibits the biogenesis of circRNAs. b Base-pairing regulators. c. Splicing factors have dual roles in the biogenesis of circRNAs. d The transcription rate of circRNA producing gene influences the expression of circRNA