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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Synthetic regulatory RNAs selectively suppress the progression of bladder cancer

Fig. 5

Effects of synthetic regulatory RNAs on cell proliferation and apoptosis. (a, b and c) Cells were seeded in 96-well plates and transfected with various vectors that were packed into lentivirus. ANOVA was used to analyze the data. There was no difference between the NC amiRNA + GAL4-VP64 + iRNA + aRNA group and the MYC amiRNA + GAL4-VP64 + iRNA + aRNA group in HFF (a). Cell proliferation was significantly decreased in T24 (b) and 5637 (c) between these two groups. (d, e and f) Without aRNA, there was no significant difference in the caspase-3 activity between column 1 and 2 in HFF (D), T24 (e) and 5637 (f). When the cells were transfected with aRNA driven by the mutant hTERT promoter, the caspase-3 activity was statistically increased in column 4 compared with column 3 in T24 (e) and 5637 (f) (both P < 0.01). However, no difference was present in HFF between column 3 and 4 (D). All data are shown as the mean ± SD (*p < 0.05, **p < 0.01); bar, SD

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