Fig. 2
From: CLDN6 promotes chemoresistance through GSTP1 in human breast cancer
Overexpression of CLDN6 affected chemoresistance in response to ADM in MCF-7 cells. a RT-PCR and western blot verified CLDN6 overexpression in CLDN6-overexpressed MCF-7 cells (MCF-7/CLDN6). b IC50 of ADM, DDP, and 5-FU when overexpressed CLDN6 in MCF-7 cells. c DAPI nuclear staining was applied to detect ADM-induced apoptosis in MCF-7/CLDN6 cells. d Apoptosis associated proteins expression in MCF-7/CLDN6 treated with the same dose of ADM by using western blot assay. e Expression of γH2AX, p53, and p-p53 in MCF-7/CLDN6 cells when treated with ADM. *,P < 0.05; **, P < 0.01