Fig. 4

Overexpression of miR-193a suppresses the formation of prostate xenograft tumors in vivo. a Fluorescence microscope is used for detecting transfection efficiency for LV-miR-193a transfection. b and c Subcutaneous tumors formed in nude mice by PC3 cells with stably overexpression of miR-193a or control at 28 days. d Tumor volume of miR-193a-overexpressiong PC3 cells at indicated time. e Histograms describing the mean tumor weights of each group. f Immunohistochemical staining of Ki-67, CD31, and CD34 in the endpoint tumors. Scale bars represent 50 μm. Each bar represents the mean ± SD of three independent experiments. *P < 0.05