Fig. 2

MiR-361-5p suppresses breast cancer cells proliferation, invasion and metastasis in vitro and in vivo. a Real-time cell proliferation assays in BC cells with miR-361-5p overexpression or inhibition. b Colony formation assays in BC cell with miR-361-5p overexpression or inhibition. c Effect of miR-361-5p on the invasion ability of BC cells using transwell assays. d The tumor weight in nude mice injected with indicated cells (left panel). Representative images of the mice injected with indicated cells (right panel). e Effect of miR-361-5p on tumor metastasis in SCID mice injected with indicated cells. The number of lung metastatic nodes in mice injected with indicated cells (left panel). Representative images of lung metastasis (right upper panel). Representative images of HE staining of the lung sections (right lower panel). *P < 0.05, **P < 0.01, ***P < 0.001