Fig. 2

Gastric cancer cells survived and induced angiogenesis in larval zebrafish (fli-eGFP). a Typical images of subintestinal vessels of uninjected embryo at 3 dpf. AGS cells (b) and SGC-7901 cells (c) were injected to the zebrafish embryos, and induced angiogenesis at 1 dpi. 50 nM VRI can block angiogenesis of the subintestinal vessels caused by cell lines AGS (d) and SGC-7901 (e). The white boxes at lower right corner showed the higher magnification of the upper left white boxes. The arrow indicated the tumor cell-induced angiogenesis. Hpf: hours post fertilization; dpi: days post injection