Fig. 4
Inhibition of cell proliferation and tumor growth by DOX and LIUS. a, b, OSCC cells were stained with Hoechst 33,258 at 24 h after treatment, and representative images were obtained using fluorescence microscopy. c, DOX in combination with LIUS inhibits SAS tumor growth in BALB/c mice. The tumor volumes per mouse (mm3) are presented as means of 5 mouse tumors from each group. d, The effect of DOX plus ultrasound on the survival of BALB/c mice transplanted with SAS human OSCC xenografts. The DOX + LIUS group had longer OS compared with Control group (p < 0.05). Data represent means ± SD of three independent experiments. # p < 0.05 versus each control