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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: ID1 promotes hepatocellular carcinoma proliferation and confers chemoresistance to oxaliplatin by activating pentose phosphate pathway

Fig. 4

G6PD rescues HCC oxaliplatin chemoresistance by promoting HCC cell proliferation and inhibits apoptosis in spite of ID1 knockdown. a The oxaliplatin chemoresistance of HCC cells was evaluated by CCK-8 assay. After transfection with G6PD plasmid, the IC50 value in 97H–OXA-shID1 + G6PD cells or 3B–OXA-shID1 + G6PD cells was increased, as compared with their control cells (P = 0.005 and P = 0.001, respectively). b CCK-8 assay showed that cell proliferation of 97H–OXA-shID1 and 3B–OXA-shID1 was recovered upon G6PD transfection (* P < 0.05). c Cell apoptosis was determined by flow cytometry. The number of apoptotic 97H–OXA-shID1 + G6PD and 3B–OXA-shID1 + G6PD cells was decreased compared with their control cells (P = 0.002 and P = 0.0015)

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