Fig. 4From: ID1 promotes hepatocellular carcinoma proliferation and confers chemoresistance to oxaliplatin by activating pentose phosphate pathwayG6PD rescues HCC oxaliplatin chemoresistance by promoting HCC cell proliferation and inhibits apoptosis in spite of ID1 knockdown. a The oxaliplatin chemoresistance of HCC cells was evaluated by CCK-8 assay. After transfection with G6PD plasmid, the IC50 value in 97H–OXA-shID1 + G6PD cells or 3B–OXA-shID1 + G6PD cells was increased, as compared with their control cells (P = 0.005 and P = 0.001, respectively). b CCK-8 assay showed that cell proliferation of 97H–OXA-shID1 and 3B–OXA-shID1 was recovered upon G6PD transfection (* P < 0.05). c Cell apoptosis was determined by flow cytometry. The number of apoptotic 97H–OXA-shID1 + G6PD and 3B–OXA-shID1 + G6PD cells was decreased compared with their control cells (P = 0.002 and P = 0.0015)Back to article page