Fig. 7

Schematic illustration of the proposed molecular mechanism of ID1-induced PPP activation and chemoresistance in HCC. ID1 regulated c-MYC through Wnt/ β-catenin pathway activation, which in turn promoted G6PD promoter transcription and activated the PPP. Activation of the PPP provided more NADPH production and downregulated intracellular ROS levels, thus encouraging chemoresistance in HCC