Fig. 5

Codon-specific selection on tumor somatic mtDNA mutations. a The correlation between numbers of mutation-caused codon from observed and simulated data. Red circles showed 4 codons which were significantly deviated from trend line. b Residuals and standardized residuals of four outliers in (a) were shown. c Heteroplasmic level of mutation-caused codons. Mean ± SEM, t test was used