Fig. 6

Amino acid-specific selection on tumor somatic mtDNA mutations. a The correlation between the number of mutation-caused amino acid from observed and simulated data. Red circles showed the mutation-caused threonine and terminator deviated from trend line. b Two outliers in (a). Standardized residuals indicate threonine and terminator are selected. c Heteroplasmic level of mutation-caused threonine and Terminator. Mean ± SEM, t test was used