Fig. 7

Functionality of tumor somatic mtDNA mutations under site-specific selection. a Proportion of mutations with high and medium impact in different coding regions. b Proportion of mutations with high impact in ATP6 and ATP8 coding regions. c Proportion of deleterious mutations in stem or loop and variable regions of tRNA. d Proportion of mutations with high impact in mutation-caused codons with significant positive and negative selection. e Proportion of mutations with high impact in mutation-caused threonine and terminator. Chi-square test was used