Fig. 4
From: MicroRNA-150 enhances radiosensitivity by inhibiting the AKT pathway in NK/T cell lymphoma
AKT2 and AKT3 are direct targets of miR-150 in NKTL. a Schematic representation of AKT2 and AKT3 UTR showing putative miR-150 target sites; b Relative luciferase activity were performed to detect the expression of wild-type/mutant AKT2 and AKT3 upon transfection with miR-150 or miR-control (normalized to firefly luciferase activity); c Relative ratio of AKT2 and AKT3 reporter constructs in Hank-1 and NK-92 cell lines, co-transfected with miR-150 or miR-control is shown; d Western blot analysis showed the expression levels of total AKT, p-AKT, AKT2 and AKT3 proteins in NKTL cells treated with miR-150 and miR-control. (Student’s t-test). #P < 0.05, *P < 0.01