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Table 1 NIH-approved clinical trials involving repurposed drugs (Metformin, Disulfiram, Chloroquine) for the treatment of GBM and other brain cancers

From: Drug repurposing for the treatment of glioblastoma multiforme

NCT Number Title of the study Disease Interventions Clinical Phase
NCT02780024 Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM GBM •Drug: Metformin Phase 2
NCT03151772 Bioavailability of Disulfiram and Metformin in Glioblastomas GBM •Drug: Disulfiram
•Drug: Metformin
Early Phase 1
NCT01430351 Phase I Factorial Trial of Temozolomide, Memantine, Mefloquine, and Metformin for Post-Radiation Therapy (RT) Glioblastoma Multiforme (GBM) Brain Cancer •Drug: Temozolomide
•Drug: Memantine
•Drug: Mefloquine
•Drug: Metformin
Phase 1
NCT02149459 Treatment of Recurrent Brain Tumors: Metabolic Manipulation Combined With Radiotherapy Brain Neoplasms •Radiation: Partial brain reirradiation.
•Drug: Metformin
•Behavioral: low carbohydrate diet
Phase 1
NCT01777919 Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiforme GBM •Drug: Temozolomide
•Drug: Disulfiram
•Drug: Copper
Phase 2
NCT01907165 Disulfiram in Treating Patients With Glioblastoma Multiforme After Radiation Therapy With Temozolomide GBM •Drug: Temozolomide
•Drug: Disulfiram
•Dietary
Supplement:
Copper gluconate
Early Phase 1
NCT02715609 Disulfiram/Copper With Concurrent Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma GBM •Drug: Disulfiram
•Drug: Copper Gluconate
•Procedure: Surgery
•Radiation: Radiation
•Drug: Temozolomide
Phase 1
Phase 2
NCT03151772 Bioavailability of Disulfiram and Metformin in Glioblastomas GBM •Drug: Disulfiram
•Drug: Metformin
Early Phase 1
NCT03034135 Safety, Tolerability and Efficacy of Disulfiram and Copper Gluconate in Recurrent Glioblastoma Recurrent GBM •Drug: Disulfiram/Copper Phase 2
NCT02678975 Disulfiram in Recurrent Glioblastoma Glioma and GBM •Drug: Disulfiram
•Dietary Supplement: Copper
•Drug: Alkylating agents
Phase 2
Phase 3
NCT02770378 A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With
Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma
GBM •Drug: Temozolomide
•Drug: Aprepitant
•Drug: Minocycline
•Drug: Disulfiram
•Drug: Celecoxib
•Drug: Sertraline
•Drug: Captopril
•Drug: Itraconazole
•Drug: Ritonavir
•Drug: Auranofin
Phase 1
NCT00224978 Chloroquine for Treatment of Glioblastoma Multiforme GBM •Drug: Chloroquine Phase 3
NCT02378532 The Addition of Chloroquine to Chemoradiation for Glioblastoma GBM •Drug: Chloroquine
•Radiation: Radiotherapy
•Drug: Temozolomide
Phase 1
NCT02432417 The Addition of Chloroquine to Chemoradiation for Glioblastoma High-grade astrocytoma
GBM
•Drug: Chloroquine Phase 2
  1. Source: https://clinicaltrials.gov/