Fig. 4

Upregulation of miR-141-3p represses invasion and migration abilities of PCa cells in vitro. a-c GSEA revealed that low expression of miR-141-3p expression significantly correlated with metastatic propensity. d Upreulating miR-141-3p suppressed invasion and migration abilities in PC-3 cells. Error bars represent the mean ± S.D. of three independent experiments. *P < 0.05. e and f Overexpression of miR-141-3p inhibited, while silencing miR-141-3p enhanced invasion (e) and migration (f) abilities in VCaP and C4-2B cells. Error bars represent the mean ± S.D. of three independent experiments. *P < 0.05