Fig. 4From: FOXA1 inhibits hepatocellular carcinoma progression by suppressing PIK3R1 expression in male patientsFOXA1 directly inhibits PIK3R1 transcription. FOXA1 directly binds to the PIK3R1 promoter sequence (a) and suppresses PIK3R1 transcription (b). Knockdown of PI3Kp85 reverses the increase in cell proliferation induced by downregulation of FOXA1 (c-e) (EdU magnification ×400)Back to article page