Skip to main content

Table 1 Characteristics and sensitivity of colorectal cancer cell lines to valproic acid and 5′-deoxy-5-fluorouridine (5′-DFUR)

From: Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53

Cell lines

p53

KRAS

B-RAF

PI3KCA

IC50 96 h

VPA, mM ± SD

IC50 96 h

5′-DFUR, μM ± SD

HT29

mut (R273H)

wt

mut

mut

3.35 ± 0.49

9.88 ± 2.14

SW620

mut (R273H)

mut (G12 V)

wt

wt

2.01 ± 0.52

35.31 ± 5.95

HCT-116

wt

mut (G13D)

wt

mut

1.41 ± 0.19

2.16 ± 0.43

HCT-116 p53−/−

null

mut (G13D)

wt

mut

2.35 ± 0.43

3.41 ± 0.68

  1. IC50 values were computed at 96 h of treatment (mean ± standard deviation (SD) from at least three separate experiments performed in quadruplicates); (mut is for mutant and wt for wild-type)