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Table 3 GO and KEGG pathway analysis of 44 gene

From: Identification and validation of a 44-gene expression signature for the classification of renal cell carcinomas

Data source Feature ID Name Genes P Value
GO Molecular Function GO:0031995 insulin-like growth factor II binding IGFBP1, IGFBP6 1.25E-04
GO Molecular Function GO:0031994 insulin-like growth factor I binding IGFBP1, IGFBP6 1.60E-04
GO Molecular Function GO:0005539 glycosaminoglycan binding SERPINA5, VCAN 1.00E-03
GO Molecular Function GO:0016597 amino acid binding ASS1, PAH 1.00E-03
GO Biological Process GO:0007588 excretion AQP6, ATP6V0A4, SLC12A1, UMOD 1.76E-06
GO Biological Process GO:0071242 cellular response to ammonium ion ASS1, SLC18A2 4.50E-06
GO Biological Process GO:0048878 chemical homeostasis SLC12A1, UMOD 1.35E-05
GO Biological Process GO:0051412 response to corticosterone FOSB, MAOB, SLC18A2 1.38E-05
GO Cellular Component GO:0005615 extracellular space ANGPTL4, DEFB1, FLRT3, HILPDA, IGFBP1, IGFBP6, LCN2, MMP7, SERPINA5, SFTPB, TACSTD2, UMOD, VCAN 8.42E-07
GO Cellular Component GO:0016324 apical plasma membrane AQP6, ATP6V0A4, MAL, RHCG, SLC12A1, UMOD 2.02E-05
GO Cellular Component GO:0005576 extracellular region ANGPTL4, C7, DEFB1, IGFBP1, IGFBP6, LCN2, MMP7, PLIN2, SERPINA5, TFPI2, UMOD, VCAN 3.77E-05
GO Cellular Component GO:0005578 proteinaceous extracellular matrix ANGPTL4, FLRT3, MMP7, TFPI2, VCAN 1.43E-04
Cancer Gene Index [CGI] C4863 prostate cancer AKR1C2, ANGPTL4, ASS1, GSTA1, IGFBP1, IGFBP6, LCN2, MAL, MT1G, S100A2, TFPI2, VCAN 3.20E-06
DISEASE DB (Univ of Copenhagen) DOID:6245 Renal oncocytoma AQP6, CLDN8, KRT7 6.14E-06
Cancer Gene Index [CGI] C9385 renal-cell cancer ASS1, DEFB1, IGFBP6, LCN2, SERPINA5, UMOD, VCAN 1.41E-05
Cancer Gene Index [CGI] C2978 cysts GSTA1, IGFBP1, IGFBP6, LCN2, MAL, UMOD 1.45E-05
KEGG path:hsa05030 Cocaine addiction FOSB, MAOB, SLC18A2 1.68E-04
REACTOME REACT_15518 Transmembrane transport of small molecules ABCA8, AQP6, ATP6V0A4, LCN2, RHCG, SLC12A1, SLC18A2 2.28E-04
KEGG path:hsa05031 Amphetamine addiction FOSB, MAOB, SLC18A2 4.19E-04
KEGG path:hsa01230 Biosynthesis of amino acids ALDOB, ASS1, PAH 1.00E-03
KEGG path:hsa00360 Phenylalanine metabolism MAOB, PAH 1.00E-03