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Table 4 Top 20 enriched pathways of 55 genes within network

From: Identification and validation of a 44-gene expression signature for the classification of renal cell carcinomas

Feature ID Name Data source Genes P Value
WP366 TGF beta Signaling Pathway WIKIPATHWAYS APP ATF2 EP300 FOSB HDAC1 MYC PTK2 SP1 TP53 4.97E-07
WP138 Androgen receptor signaling pathway WIKIPATHWAYS EP300 HDAC1 KAT5 MDM2 PTK2 RELA SP1 4.27E-06
path:hsa05202 Transcriptional misregulation in cancer KEGG CEBPB HDAC1 MDM2 MYC PTK2 RELA SP1 TP53 2.02E-05
WP2377 Integrated Pancreatic Cancer Pathway WIKIPATHWAYS APP EGR1 EP300 HNF4A MDM2 MYC SP1 TP53 3.49E-05
path:hsa05169 Epstein-Barr virus infection KEGG ATF2 CD44 EP300 HDAC1 MDM2 MYC RELA TP53 4.12E-05
path:hsa05030 Cocaine addiction KEGG ATF2 FOSB MAOB RELA SLC18A2 1.33E-04
REACT_169274 Cellular Senescence REACTOME CEBPB MDM2 RELA SP1 TERF1 TP53 UBC 3.43E-04
path:hsa05031 Amphetamine addiction KEGG ATF2 FOSB HDAC1 MAOB SLC18A2 4.35E-04
REACT_169325 Oncogene Induced Senescence REACTOME MDM2 SP1 TP53 UBC 4.68E-04
REACT_120734 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription REACTOME HDAC1 MYC SP1 UBC 1.00E-03
path:hsa05220 Chronic myeloid leukemia KEGG HDAC1 MDM2 MYC RELA TP53 1.00E-03
REACT_120956 Cellular responses to stress REACTOME CEBPB EP300 MDM2 RELA SP1 TERF1 TP53 UBC 1.00E-03
WP1984 Integrated Breast Cancer Pathway WIKIPATHWAYS EP300 HDAC1 MDM2 MYC SP1 TP53 1.00E-03
REACT_121061 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer REACTOME HDAC1 MYC SP1 UBC 1.00E-03
path:hsa05166 HTLV-I infection KEGG ATF2 EGR1 EP300 KAT5 MYC RELA TP53 2.00E-03
WP399 Wnt Signaling Pathway and Pluripotency WIKIPATHWAYS CD44 EP300 MMP7 MYC TP53 2.00E-03
REACT_118780 NOTCH1 Intracellular Domain Regulates Transcription REACTOME EP300 HDAC1 MYC UBC 2.00E-03
REACT_299 Signaling by NOTCH REACTOME EP300 HDAC1 MYC TP53 UBC 3.00E-03
h_arfPathway Tumor Suppressor Arf Inhibits Ribosomal Biogenesis BIOCARTA MDM2 MYC TP53 3.00E-03