Table 1 Comparison of clinical, morphology, immunophenotype and genetics features between SMCL and classic MCL
SMCL | Classic MCL | |
|---|---|---|
Clinical features | ||
B symptom | without | with or without |
Serum LDH | normal | elevated or normal |
Serum β2-MG | normal | elevated or normal |
MIPI | low risk | low to high risk |
Ki-67 | < 30% | ≥30% |
Max tumor diameter | < 3 cm | ≥3 cm |
SUV of PET/CT | ≤ 6 | > 6 |
evaluation every 3 mons | no tumor growth | having tumor growth |
Morphology | ||
Origin | germinal or post-germinal center | antigen-naïve pregerminal center |
Cytology | non-blastoid/pleomorphic | small cell, classic, pleomorphic, or blastic |
Immunophenotype | ||
CD5 | low | high |
CD38 | low | high |
CD23 | high | low |
CD200 | high | low |
light chain restriction | kappa | lambda |
Genetics | ||
TP53 | low | high |
NOTCH1/2 | low | high |
C-myc | low | high |
Cyclin D1 mRNA | low | high |
Cell cycle | G1 or before | S |