Fig. 2

LXA4 reverses mesenchymal phenotypes of pancreatic cancer cells mediated by FPRL1. a Panc-1 and MIA PaCa-2 cells were treated with vehicle or gradient concentration of LXA4 (0, 100, 200, 400, 800 nM) for 48 h. Then E-cadherin, N-cadherin and Vimentin were detected by western blotting. b The morphology was recorded with or without 400 nM LXA4 treatment for 48 h. c Both of the cells were transfected with siRNA targeting FPRL1 (siFPRL1) or negative control (siNC), and 48 h later, 400 nM LXA4 or vehicle were used to treat these cells for 48 h. Then E-cadherin, N-cadherin and Vimentin were detected by western blotting