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Table 1 Methods for ALT diagnosis in cell cultures and tumor specimens

From: Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?

  Cell culture Tumor specimens
Telomerase activity RTQ-TRAP RTQ-TRAP
Telomere’s lenght Southern blot
Q-FISH
Q-FISH
c-circles quantification c-circle assay c-circle assay
TERRA detection Northern blot
RNA Fish
RNA Fish
ATRX/DAXX expression Western blot
Immunohistochemistry
RTQ-PCR
Microarray
Deep sequencing
Immunohistochemistry
RTQ-PCR
Microarray
Deep sequencing
APB detection Co-IF FISH Co-IF FISH