Fig. 9

Knockdown of AK023391 inhibited tumor growth in vivo. a Schematic representation of the SGC-7901 xenograft tumor size after 30 d of tumor growth in the si-AK023391 and negative control (NC)groups. b Tumor growth curve of the SGC-7901 xenograft tumor growth tendency in the si-AK023391 and NC groups. c Statistical comparison of the differences in tumor weight and volume between the si-AK023391 and NC groups. d IHC analysis of the expression levels of Ki-67, p-FOXO3a, p-PI3K, p-Akt, and p-NF-κB in xenograft tumor tissues treated with si-AK023391 and in the NC group (original magnification, ×200). e LncRNA AK023391 promoted GC tumorigenesis and invasion through activation of the PI3K/Akt pathway that further activated NF-κB, inactivated FOXO3a, upregulated c-myb, cyclinB1/G2, and BCL-6, and downregulated p53 expression