Fig. 1

MCM6 expression is significantly up-regulated in HCC and indicates poor prognosis. a Representative IHC images of MCM6 expression in 30 normal hepatic tissues and 70 paired HCC and adjacent non-tumor tissues. The upper left two panels represent paired HCC and non-tumor tissues and reveal high MCM6 expression in HCC tissues and low expression in adjacent non-tumor tissues. The upper right panel represents normal hepatic tissues and reveals no MCM6 expression. Scale bars, 50 μm. Lower panels represent magnified pictures of the boxed area in the corresponding upper panels. b MCM6 expression levels were compared among HCC, adjacent non-tumor and normal hepatic tissue specimens. ** P < 0.01. c-d Prognostic significance assessed by Kaplan–Meier survival estimates and log rank tests. Comparison of the time to recurrence (TTR) and overall survival (OS) by MCM6. e MCM6 was correlated with early recurrence in HCC patients based on TCGA datasets. f-g TCGA clinical data showing TTR and OS curves for HCC of MCM6 expression