Fig. 7

Schematic representation of a novel combination therapy for advanced colorectal cancer. Schematic representation of a novel combination therapy using ONC201 (top) and bevacizumab (bottom). The treatments invoke complementary yet non-overlapping independent mechanisms to increase tumor cell death and inhibit proliferation. (Top) ONC201 mechanism of action as defined by upregulation of TRAIL and DR5. (Bottom) Bevacizumab’s mechanism of action as defined by inhibition of VEGF in tumor and peripheral cells, leading to a decrease in blood vessel development