Fig. 6From: SMURF1 facilitates estrogen receptor ɑ signaling in breast cancer cellsThe hypothetical model for the positive feedback loop between SMURF1 and ER alpha signaling in breast cancer cells: ER alpha signaling induces the expression of SMURF1, which subsequently stabilizes ER alpha via its HECT domain possibly by inhibiting ER alpha K48-linked polyubiqutination processBack to article page