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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells

Fig. 6

High MCT1 expression correlated positively with LC3B in HCC tissues. (a) The expression levels of MCT1 in 85 pairs of tumor tissues and adjacent tissues were detected by real-time PCR. (b) The representative expression of MCT1 levels in adjacent tissues (N) and tumor tissues (T) by Western blot. (c) Representative immunostaining of MCT1 in HCC tissues and adjacent tissues (magnification: ×100, ×200). (d) Pearson correlation to analyse the expression relationship between MCT1 mRNA and LC3B mRNA in 85 HCC tissues (r = 0.676, P < 0.001). (e) Relative MCT1 expression in metastatic(n = 11) cases versus non-metastatic cases(n = 74). (f) Correlation between autophagy marker LC3B and metastasis. (g) A Schematic model of autophagy promoting MCT1 expression by β-catenin to influence glycolysis in HCC. *p < 0.05, **p < 0.01

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