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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia

Fig. 4

SGK3 is required for INPP4B-induced cell proliferation in OCI-AML3 cells. qRT-PCR (a) and western blotting (b) analysis of SGK3 expression from the OCI-AML3 cells transduced with the control siRNA or siSGK3. c CCK-8 assay analysis of cell proliferation activity in the siSGK3 transduced cells. d The INPP4B-silenced OCI-AML3 cells were transfected with the pCMV-Flag/SGK3 plasmids, western blotting analysis of SGK3, p-SGK3T320 and INPP4B. Proteins were quantified using image software and normalized against β-actin. e CCK-8 assay analysis of cell proliferation in INPP4B-silenced OCI-AML3 cells, followed by Flag-SGK3 introduction. Data were represented as mean ± s.d. of three individual experiments. * p < 0.05, as comparison to mock or control group, respectively; # p < 0.05, as comparison to shINPP4B group

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